Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient

Heng Zheng; Yingying Cui; Fengli Fu; Fang Peng; Xiaomin Dai

doi:10.1111/pin.70095

Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient

Pathol Int. 2026 Feb;76(2):e70095. doi: 10.1111/pin.70095.

Authors

Heng Zheng¹, Yingying Cui², Fengli Fu³, Fang Peng¹, Xiaomin Dai¹

Affiliations

¹ Department of Pathology, Zhejiang Hospital, Hangzhou, Zhejiang, China.
² Department of General Surgery, Yuyao Traditional Chinese Medicine Hospital, Ningbo, Zhejiang, China.
³ Department of Radiology, Zhejiang Hospital, Hangzhou, Zhejiang, China.

PMID: 41653129
DOI: 10.1111/pin.70095

Abstract

SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features. The application of the SMARCA4 immunohistochemical marker facilitates accurate identification. This study presents a rare case of SMARCA4-deficient pulmonary invasive mucinous adenocarcinoma with high-grade transformation.

Publication types

Case Reports
Letter

MeSH terms

Adenocarcinoma of Lung / pathology
Adenocarcinoma, Mucinous* / genetics
Adenocarcinoma, Mucinous* / metabolism
Adenocarcinoma, Mucinous* / pathology
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung* / pathology
DNA Helicases* / deficiency
DNA Helicases* / genetics
Female
Humans
Lung Neoplasms* / genetics
Lung Neoplasms* / metabolism
Lung Neoplasms* / pathology
Male
Middle Aged
Nuclear Proteins* / deficiency
Nuclear Proteins* / genetics
Transcription Factors* / deficiency
Transcription Factors* / genetics

Substances

SMARCA4 protein, human
DNA Helicases
Nuclear Proteins
Transcription Factors
Biomarkers, Tumor