CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease

Alzheimers Res Ther. 2026 Feb 7. doi: 10.1186/s13195-026-01982-0. Online ahead of print.

¹ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
² Center for Regenerative Biotherapeutics, Mayo Clinic, Jacksonville, FL, 32224, USA.
³ Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
⁴ Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
⁵ Present address: Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
⁶ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. Li.Yonghe@mayo.edu.

No abstract available

Keywords: CI-994; Drug repurposing; Histone deacetylases; Wnt/β-catenin signaling; iPSC-derived cerebral organoids; iPSC-derived neurons.

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