Abstract
Bonta, Sorenson and others have shown that Cu(II) derivatives are effective anti-inflammatory agents. Some chemical and pharmacological properties of Cu(I) and metallic Cu are discussed. Thio complexes of Cu(I) were prepared and shown to be useful anti-inflammatory agents in rats. Hypotheses are stated concerning the possible therapeutic value of copper in its various oxidation states.
MeSH terms
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Animals
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Anti-Inflammatory Agents* / history
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Anti-Inflammatory Agents, Non-Steroidal
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Arthritis, Experimental / drug therapy
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Chemistry
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Copper / history
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Copper / pharmacology*
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Copper / toxicity
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Female
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Gold / pharmacology
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Gold Sodium Thiomalate / chemical synthesis
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History, Ancient
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Irritants
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Male
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Rats
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Thiomalates / chemical synthesis
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Irritants
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Thiomalates
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Gold Sodium Thiomalate
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Gold
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Copper