Shedding light on interventions for brain aging

Juan Zhang; Qiang Liu

doi:10.1016/j.immuni.2026.01.021

Shedding light on interventions for brain aging

Immunity. 2026 Feb 10;59(2):235-237. doi: 10.1016/j.immuni.2026.01.021.

Authors

Juan Zhang¹, Qiang Liu²

Affiliations

¹ Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui 241002, China.
² Hefei National Research Center for Physical Sciences at the Microscale, Department of Anesthesiology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China; Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, Anhui 230027, China; Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. Electronic address: liuq2012@ustc.edu.cn.

PMID: 41672040
DOI: 10.1016/j.immuni.2026.01.021

Abstract

Immunotherapeutic approaches to brain aging remain largely preclinical and in early translational stages, and they have focused mostly on modulating innate immunity. In this issue of Immunity, Negredo et al. identify T cells bearing exhaustion-like signatures as a hallmark of brain aging and reveal the beneficial effects of an engineered IL-10 variant that functionally uncouples pro- and anti-inflammatory signaling in microglia.

Publication types

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MeSH terms

Aging* / immunology
Animals
Brain* / immunology
Brain* / physiology
Humans
Immunity, Innate
Interleukin-10 / genetics
Interleukin-10 / immunology
Mice
Microglia / immunology
T-Lymphocytes* / immunology

Substances

Interleukin-10