Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles

Cancer Res. 1978 May;38(5):1410-3.

Abstract

Indole-3-carbinol, 3,3'-diindolylmethane, and indole-3-acetonitrile, three indoles occurring in edible cruciferous vegetables, have been studied for their effects on 7,12-dimethylbenz(a)anthracene-induced mammary tumor formation in female Sprague-Dawley rats and on benzo(a)pyrene-induced neoplasia of the forestomach in female ICR/Ha mice. When given by p.o. intubation 20 hr prior to 7,12-dimethylbenz(a)anthracene administration, indole-3-carbinol and 3,3'-diindolylmethane had an inhibitory effect on mammary tumor formation, but indole-3-acetonitrile was inactive. Indole-3-carbinol when added to the diet for 8 days prior to challenge with 7,12-dimethylbenz(a)anthracene inhibited mammary tumor formation, whereas indole-3-acetonitrile did not. Dietary administration of all three indoles inhibited benzo(a)pyrene-induced neoplasia of the forestomach in ICR/Ha mice. The identification of dietary constituents that can inhibit chemical carcinogens ultimately may be of value in understanding the balance of factors that determines the neoplastic response to these cancer-producing agents in the environment.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene*
  • Acetonitriles / pharmacology
  • Animals
  • Benz(a)Anthracenes*
  • Diet*
  • Female
  • Indoles / pharmacology*
  • Mammary Neoplasms, Experimental / chemically induced
  • Mammary Neoplasms, Experimental / prevention & control*
  • Mice
  • Mice, Inbred ICR
  • Neoplasms, Experimental / prevention & control
  • Rats
  • Stomach Neoplasms / chemically induced
  • Stomach Neoplasms / prevention & control*

Substances

  • Acetonitriles
  • Benz(a)Anthracenes
  • Indoles
  • 9,10-Dimethyl-1,2-benzanthracene
  • indole-3-acetonitrile
  • indole-3-carbinol
  • 3,3'-diindolylmethane