Introduction: Sickle cell disease is associated with painful vaso-occlusive crises, bone infarction, avascular necrosis, and osteomyelitis. Sickle cell orbitopathy is a rare manifestation with signs similar to periorbital cellulitis and has subtle radiologic features.
Case presentation: We report a case of a five-year-old girl with sickle cell who presented with bilateral orbital infarctions and subperiosteal hematomas, notably without periorbital pain, and was treated with antibiotics and steroids.
Conclusion: Physicians should be aware of this rare manifestation, especially in the pediatric population, as it can affect subsequent management.
Keywords: Case report; Infarctions; Orbital bone infarction; Sickle cell crisis.
© 2026 The Author(s). Published by S. Karger AG, Basel.