Best evidence summary on sexual health management for patients undergoing intracavitary brachytherapy for gynecological neoplasms

Front Oncol. 2026 Jan 29:16:1770806. doi: 10.3389/fonc.2026.1770806. eCollection 2026.

Abstract

Objective: To systematically retrieve, appraise and synthesize the best available evidence on sexual health management in patients undergoing intracavitary brachytherapy for cervical cancer, so as to provide an evidence-based foundation for developing individualized sexual-health care plans in clinical practice.

Methods: A comprehensive computer-based search of domestic and foreign databases, guideline repositories and professional association websites was conducted for all evidence on sexual health management in cervical-cancer patients receiving intracavitary brachytherapy. Document types included guidelines, evidence summaries, systematic reviews, expert consensus statements and clinical decision aids. The search timeframe spanned database inception to June 2025.

Results: Twelve publications were ultimately included: two clinical decision aids, one guideline, four systematic reviews, two evidence summaries, one expert consensus and two randomized controlled trials. Thirty-nine evidence statements were extracted and grouped under seven themes: target population and risk factors, screening and assessment, health education, non-pharmacologic interventions, pharmacologic and hormonal therapies, special treatments, and follow-up.

Conclusion: This study summarizes the best current evidence on sexual health management for cervical-cancer patients undergoing intracavitary brachytherapy and offers valuable guidance for improving patients' quality of life and sexual-health outcomes.

Systematic review registration: http://ebn.nursing.fudan.edu.cn/home, identifier ES20256976.

Keywords: brachytherapy; evidence summary; gynecologic oncology; sexual health; uterine cervical neoplasms.

Publication types

  • Systematic Review