Overexpression of PGRMC2 in astrocytes improved cognitive function in a mouse model of Alzheimer's disease by modulating neuroinflammation
J Transl Med
.
2026 Feb 14.
doi: 10.1186/s12967-026-07862-3.
Online ahead of print.
Authors
Taiyang Zhu
1
,
Chao Zhou
2
,
Hui Zhou
1
,
Fanyu Shen
1
,
Shang Wang
3
,
Yan Zhou
1
,
Guoliang Jin
1
,
Jie Zu
1
,
Xinxin Yang
1
,
Hongjuan Shi
1
,
Guiyun Cui
4
,
Fang Hua
5
Affiliations
1
Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
2
Department of Neurology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.
3
Department of Human Anatomy, Kangda College of Nanjing Medical University, Lianyungang, China.
4
Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China. cuiguiyun-js@163.com.
5
Division of Human Anatomy, College of Allied Health Science, Augusta University, Augusta, GA30912, USA. fhua@augusta.edu.
PMID:
41699609
DOI:
10.1186/s12967-026-07862-3
No abstract available
Keywords:
Alzheimer’s disease; Astrocyte; Neuroinflammation; PGRMC2.
Grants and funding
82171420/National Natural Science Foundation of China