Alpha-B-crystallin immunohistochemistry: A sensitive but non-specific marker for epileptogenic lesions

Brain Pathol. 2026 Feb 18:e70087. doi: 10.1111/bpa.70087. Online ahead of print.

Ekin Güney¹, Ilay Caliskan¹, Tara Saunders¹, Mercedes Paredes², Calixto-Hope Lucas^{1

3}, Kanish Mirchia¹, Rufei Lu^{1

4}, Merryl Terry¹, Erika Cagampan⁵, Melike Pekmezci¹, Andrew Bollen¹, Arie Perry^{1

6}, Cathryn R Cadwell^{1

6

7

8}, Tarık Tihan⁹

¹ Department of Pathology, University of California San Francisco, San Francisco, California, USA.
² Department of Neurology, University of California San Francisco, San Francisco, California, USA.
³ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
⁵ School of Medicine, University of California San Francisco, San Francisco, California, USA.
⁶ Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
⁷ Weill Neurohub, University of California, San Francisco, San Francisco, California, USA.
⁸ Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, California, USA.
⁹ Department of Pathology, University of Miami Health System, Miami, Florida, USA.

No abstract available

Keywords: alpha‐B‐crystallin; balloon cells; brain; epilepsy; focal cortical dysplasia; mesial temporal sclerosis; neoplasia; p16.

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