Current progress in pathway-targeted therapeutics for Alzheimer's disease: mechanistic insights and windows of opportunity

Habab Ali Ahmad; Mahnoor Zafar; Tooba Khan; Muhammad Imran Khan

doi:10.1007/s11010-026-05505-1

Current progress in pathway-targeted therapeutics for Alzheimer's disease: mechanistic insights and windows of opportunity

Mol Cell Biochem. 2026 Feb 19. doi: 10.1007/s11010-026-05505-1. Online ahead of print.

Authors

Habab Ali Ahmad^{1

2}, Mahnoor Zafar^{1

2}, Tooba Khan^{1

2}, Muhammad Imran Khan^{3

4}

Affiliations

¹ Drug Development and Biosignaling Research Laboratory, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan.
² Department of Biological and Health Sciences, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan.
³ Drug Development and Biosignaling Research Laboratory, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan. imran.khan@fbse.paf-iast.edu.pk.
⁴ Department of Biological and Health Sciences, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan. imran.khan@fbse.paf-iast.edu.pk.

PMID: 41712029
DOI: 10.1007/s11010-026-05505-1

No abstract available

Keywords: Alzheimer’s disease; Biosignaling; Clinical trials; Inhibitor-based therapeutics; Neuroinflammation; Personalized medicine; Preclinical studies; Tau pathology; β-amyloid.

Publication types

Review