Efficacy of a sexual quality of life intervention for couples facing metastatic breast cancer: Results of a randomized controlled trial

Cancer. 2026 Mar 1;132(5):e70334. doi: 10.1002/cncr.70334.

Abstract

Background: Patients with metastatic breast cancer (MBC) often report severe, long-standing concerns with their sexual quality of life (QOL), yet interventions for this population are scarce. This study evaluated the efficacy of a couple-based sexual QOL intervention adapted for MBC couples in a randomized controlled trial.

Methods: Fifty-five female MBC patients reporting sexual concerns and their intimate partners (N = 110 participants) were randomized to Adapted Intimacy Enhancement (AIE), a four-session videoconference intervention providing education and skills training for coping with sexual/intimacy concerns, or Enhanced Care-As-Usual (ECAU; informational booklet). Outcomes (measured at baseline, post-intervention, and 6-month follow-up) included patients' sexual outcomes (sexual function/distress/self-efficacy; primary), patients' psychosocial outcomes (sexual communication, relationship intimacy, and psychological distress; secondary), and similar partner outcomes (secondary). Mixed linear regression models assessed intervention effects on outcomes at follow-ups; psychosocial outcomes were analyzed using dyadic analyses. Effect sizes (Cohen's d) were calculated.

Results: Compared to ECAU, patients in AIE reported greater improvements in overall sexual function (p = .018), desire (p = .007), and sexual distress (p = .046) at 6 months, and in sexual satisfaction at both post-intervention (p = .02) and 6 months (p < .001). Partners in AIE reported greater improvements in sexual distress (p = .006), sexual self-efficacy (p = .008), sexual communication (p = .004), and relationship intimacy (p = .01) at 6 months. Effects were largest for patient sexual satisfaction and partner sexual distress at 6 months.

Conclusions: Compared to a detailed informational booklet on sex/intimacy, the couple-based AIE intervention yielded long-term benefits for MBC patients' sexual outcomes and partners' sexual distress and psychosocial outcomes. Future research should identify intervention mediators and optimal dissemination methods.

Keywords: breast cancer; dyadic coping; intimacy; randomized controlled trial; sexual dysfunction; videoconference intervention.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adaptation, Psychological
  • Adult
  • Aged
  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Quality of Life*
  • Sexual Behavior* / psychology
  • Sexual Partners* / psychology