A hemodynamic-driven approach to chronic pulmonary hypertension in congenital diaphragmatic hernia

Carly E Byrd; John T Wren Jr; Suneetha Desiraju; Patrick J McNamara

doi:10.1038/s41372-026-02582-4

A hemodynamic-driven approach to chronic pulmonary hypertension in congenital diaphragmatic hernia

J Perinatol. 2026 Feb 23. doi: 10.1038/s41372-026-02582-4. Online ahead of print.

Authors

Carly E Byrd^#¹, John T Wren Jr^#², Suneetha Desiraju¹, Patrick J McNamara³

Affiliations

¹ Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Division of Neonatology, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
³ Division of Neonatology, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Patrick-mcnamara@uiowa.edu.

^# Contributed equally.

PMID: 41731046
DOI: 10.1038/s41372-026-02582-4

Abstract

Despite ample research in acute pulmonary hypertension in neonates with congenital diaphragmatic hernia (CDH) leading to improved survival, there is a paucity of literature on the physiology of chronic pulmonary hypertension in this population. Serial hemodynamic assessments and physiology-centric care have been shown to be safe and effective in the acute transitional and peri-operative care of these neonates and will likely be informative in the discussion of chronic pulmonary hypertension as well. Herein, we discuss the epidemiology, contributors, and proposed physiology-based phenotypes of chronic pulmonary hypertension in neonates with CDH. Further investigation is needed to contribute to our understanding and treatment of chronic pulmonary hypertension in this complex, heterogeneous population.

Publication types

Review