Purpose: To assess the timeliness of referral to an outpatient palliative care clinic for patients with advanced cancer and to evaluate key markers of intervention efficacy.
Methods/patients: Retrospective study of 177 consecutive patients with advanced cancer referred to outpatient palliative care in a tertiary hospital.
Results: Median survival post-referral was 268 days (95% CI 228-308). Fatigue (48%) and pain (21%) were the most frequent symptoms. Significant symptom improvement was observed between initial and second visits: the median ESAS score dropped from 7 (5-8) to 5 (3-7) (p < 0.001). Severe ESAS scores for the primary symptom decreased from 63 to 30% (p < 0.001). Advance Care Planning (ACP) was documented in 94% of patients. 1% of deceased patients received anticancer treatment in the last 14 days, 7% in the last 30 days.
Conclusions: Early palliative care referral was associated with improved symptoms, higher rates of ACP, and reduced aggressive end-of-life care, supporting the expansion of palliative care resources.
Keywords: Advanced cancer; Outpatients; Palliative care; Quality of life; Referral and consultation; Symptom management.
© 2026. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).