Inflammation-Driven Field Cancerization in End-Stage Kidney Disease

Rebecca A Sager; Katalin Susztak; A Ari Hakimi

doi:10.1158/2159-8290.CD-25-2276

Inflammation-Driven Field Cancerization in End-Stage Kidney Disease

Cancer Discov. 2026 Mar 2;16(3):426-427. doi: 10.1158/2159-8290.CD-25-2276.

Authors

Rebecca A Sager¹, Katalin Susztak^{2

3}, A Ari Hakimi^{1

4}

Affiliations

¹ Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
² Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
³ Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
⁴ Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

PMID: 41766431
DOI: 10.1158/2159-8290.CD-25-2276

Abstract

In this issue, Takahashi, Tanaka, and colleagues provide a comprehensive genomic, transcriptomic, and spatial analysis of renal cell carcinomas (RCC) associated with end-stage renal disease. They demonstrate that the clonal expansion of a subset of proximal tubule cells, supported by an inflammatory microenvironment, gives rise to the cysts of acquired cystic kidney disease as well as to acquired cystic disease-associated RCC. See related article by Takahashi et al., p. 478.

MeSH terms

Carcinoma, Renal Cell* / etiology
Carcinoma, Renal Cell* / genetics
Carcinoma, Renal Cell* / pathology
Humans
Inflammation* / complications
Inflammation* / pathology
Kidney Failure, Chronic* / complications
Kidney Failure, Chronic* / pathology
Kidney Neoplasms* / etiology
Kidney Neoplasms* / genetics
Kidney Neoplasms* / pathology
Tumor Microenvironment