Effects and mechanisms of probiotics supplement on hypertension

J Hypertens. 2026 May 1;44(5):731-740. doi: 10.1097/HJH.0000000000004258. Epub 2026 Mar 2.

Abstract

The global population of individuals suffering from hypertension is estimated to surpass 1.28 billion. Uncontrolled hypertension makes contributions to the development of cardiovascular and cerebrovascular diseases. Emerging evidence indicates a significant correlation between hypertension and gut microbiota. As an intestinal regulator, which could confer health benefits to the host in adequate amounts, probiotics may become a novel approach to regulating blood pressure without side effects. Therefore, we overview the antihypertensive effects and the potential mechanisms of probiotics supplement on hypertension.

Keywords: gut microbiome; hypertension; probiotics supplement.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Dietary Supplements*
  • Gastrointestinal Microbiome
  • Humans
  • Hypertension* / drug therapy
  • Hypertension* / microbiology
  • Hypertension* / physiopathology
  • Hypertension* / therapy
  • Probiotics* / therapeutic use