AES ILAE North America Symposium: Guiding Evidence-Based Epilepsy Management

Nathalie Jette; Kette Valente; Nicholas S Abend; Lara Jehi; Lacey Smith; J Helen Cross

doi:10.1177/15357597261416718

AES ILAE North America Symposium: Guiding Evidence-Based Epilepsy Management

Epilepsy Curr. 2026 Feb 27:15357597261416718. doi: 10.1177/15357597261416718. Online ahead of print.

Authors

Nathalie Jette¹, Kette Valente², Nicholas S Abend³, Lara Jehi⁴, Lacey Smith⁵, J Helen Cross⁶

Affiliations

¹ Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.
² Neuroscience Unit for Epilepsy and Neurodevelopmental Disorders, University of São Paulo Medical School, São Paulo, Brazil.
³ Division of Neurology, Children's Hospital of Philadelphia; Departments of Neurology and Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
⁵ Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
⁶ Developmental Neurosciences, University College London NIHR BRC Great Ormond Street Institute of Child Health, London, UK.

Abstract

Clinical practice guidelines (CPG) provide evidence-based recommendations to optimize patient care. Their development should be rigorous and include defining the scope, conducting systematic reviews, evaluating the quality of the evidence and formulating recommendations that are linked to the evidence. When peer reviewed evidence is insufficient to inform CPGs, consensus-based recommendations (CBR) are an alternative. Both CPG and CBR are essential to inform best practices and inform health policy. This review highlights recent epilepsy CPG and CBR about genetic testing, neonatal seizures, pediatric depression, epilepsy surgery referral timing and addresses their impact on outcomes.

Keywords: Delphi; clinical practice standard; consensus-based recommendations; guideline; seizure.