Respiratory Syncytial Virus Vaccines in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians

Ann Intern Med. 2026 May;179(5):734-739. doi: 10.7326/ANNALS-25-05485. Epub 2026 Mar 3.

Abstract

Description: The American College of Physicians (ACP) developed these rapid practice points addressing the efficacy, comparative effectiveness, and harms of respiratory syncytial virus (RSV) vaccines in adults aged 18 years or older who are not pregnant or immunocompromised.

Methods: The ACP Population Health and Medical Science Committee developed the rapid practice points based on a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria.

The practice points apply to adults aged 60 years or older who are not immunocompromised.

Practice point 1: Adults aged 75 years or older should receive a protein subunit RSV vaccine.

Practice point 2: Adults aged 60 to 74 years who are at increased risk for severe RSV may consider receiving a protein subunit RSV vaccine.

Publication types

  • Practice Guideline

MeSH terms

  • Aged
  • Female
  • Humans
  • Immunocompromised Host
  • Middle Aged
  • Protein Subunit Vaccines
  • Respiratory Syncytial Virus Infections* / prevention & control
  • Respiratory Syncytial Virus Vaccines* / adverse effects
  • Respiratory Syncytial Virus Vaccines* / immunology
  • Vaccine Efficacy
  • Vaccines, Subunit / adverse effects

Substances

  • Respiratory Syncytial Virus Vaccines
  • Protein Subunit Vaccines
  • Vaccines, Subunit