Transdiagnostic neuropsychological factors in women with premenstrual dysphoric disorder and premenstrual syndrome: a comparison of the premenstrual and postmenstrual phases

Arch Womens Ment Health. 2026 Mar 4;29(2):45. doi: 10.1007/s00737-026-01684-4.

Abstract

Purpose: This study aimed to compare transdiagnostic neuropsychological factors among women with Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), and asymptomatic control groups.

Methods: Using a causal-comparative design, 150 female university students aged 20 to 35 were selected through purposive sampling. Participants were categorized into PMS, PMDD, and asymptomatic control groups based on a structured clinical interview and a screening questionnaire. Neurocognitive functioning was assessed using the Continuous Performance Test (CPT), the Go/No-Go Task, and the Iowa Gambling Task (IGT).

Results: Significant differences were observed among the three groups in sustained attention, inhibitory control, and risky decision-making. The PMDD group consistently showed lower performance than the PMS and asymptomatic control groups. Within-group phase comparisons revealed a significant decline in sustained attention only in the PMS group during the premenstrual phase, while other cognitive functions remained stable across menstrual cycle phases. No significant menstrual cycle phase changes were observed in the PMDD or asymptomatic control groups.

Conclusion: These findings indicate that women with PMDD and PMS exhibit difficulties in attention, inhibitory control, and decision-making compared to the asymptomatic control group. Such difficulties appear to be related to symptom burden, highlighting potential targets for assessment and intervention.

Keywords: Inhibition; Premenstrual dysphoric disorder; Premenstrual syndrome; Risky decision making; Sustained attention; Transdiagnostic.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Attention* / physiology
  • Cognition* / physiology
  • Decision Making
  • Female
  • Humans
  • Menstrual Cycle* / psychology
  • Neuropsychological Tests
  • Premenstrual Dysphoric Disorder* / diagnosis
  • Premenstrual Dysphoric Disorder* / psychology
  • Premenstrual Syndrome* / diagnosis
  • Premenstrual Syndrome* / psychology
  • Surveys and Questionnaires
  • Young Adult