Both chronic obstructive pulmonary disease (COPD) and lung carcinoma (LC) are major public health challenges in China. With the continuous advancement of microbial detection methods, the role of the respiratory microbiome in the pathogenesis and progression of respiratory diseases has become increasingly prominent. This article systematically reviews the dynamic characteristics of the respiratory microbiome during the progression of COPD and LC, then explores its crucial bridging role in COPD-LC comorbidity through mechanisms such as persistently driving chronic inflammation, mediating genomic damage, and participating in immune regulation. The aim is to deepen the understanding of the respiratory microbiome, and to provide new perspectives for optimizing existing treatment strategies, exploring microbial biomarkers for early cancer screening, and improving the clinical management of chronic respiratory diseases. .
【中文题目：呼吸道微生物在慢性阻塞性肺疾病 与肺癌共病中的调控机制研究进展】 【中文摘要：慢性阻塞性肺疾病（chronic obstructive pulmonary disease, COPD）与肺癌（lung carcinoma, LC）均为我国面临的重大公共卫生挑战。随着微生物检测方法的不断更新迭代，呼吸道微生物在呼吸系统疾病发生发展中的作用日益凸显。本文系统综述了COPD与LC病程中呼吸道微生物的动态特征，并探讨了其通过持续驱动慢性炎症、介导基因组损伤及参与免疫调控等机制在COPD-LC共病中发挥的关键桥梁作用，旨在深化对呼吸道微生物的认识，为优化现有治疗策略、探寻癌症早筛微生物标志物以及慢性呼吸系统疾病临床管理提供新视角。 】 【中文关键词：慢性阻塞性肺疾病；肺肿瘤；呼吸道微生物；调控机制】.
Keywords: Chronic obstructive pulmonary disease; Lung neoplasms; Regulatory mechanism; Respiratory microbiota.