Prenatally vs. Postnatally Diagnosed Congenitally Corrected Transposition of the Great Arteries is Associated with Higher Rates of Conduction Disease, Intervention and Earlier Mortality

Lynne E Nield; Mélanie Grasswill; Bénédicte Romefort; Solène Prigent; Emre Belli; Sonya V Babu-Narayan; Robert W Elder; Magalie Ladouceur; Paul Khairy; Ewa Kowalik; David M Kalfa; Miriam Conway; Oscar Werner; Jean-Marc Sellal; Astrid Monier; Edward Buratto; Paul Padovani; David J Barron; Emile A Bacha; Michael A Gatzoulis; Christopher J McLeod; Matilde Karakachoff; Alban-Elouen Baruteau; DISCO study group

doi:10.1007/s00246-026-04198-z

Prenatally vs. Postnatally Diagnosed Congenitally Corrected Transposition of the Great Arteries is Associated with Higher Rates of Conduction Disease, Intervention and Earlier Mortality

Pediatr Cardiol. 2026 Mar 4. doi: 10.1007/s00246-026-04198-z. Online ahead of print.

Authors

Lynne E Nield¹, Mélanie Grasswill², Bénédicte Romefort², Solène Prigent², Emre Belli³, Sonya V Babu-Narayan⁴, Robert W Elder⁵, Magalie Ladouceur⁶, Paul Khairy⁷, Ewa Kowalik⁸, David M Kalfa⁹, Miriam Conway⁴, Oscar Werner², Jean-Marc Sellal¹⁰, Astrid Monier², Edward Buratto¹¹, Paul Padovani², David J Barron¹², Emile A Bacha⁹, Michael A Gatzoulis⁴, Christopher J McLeod¹³, Matilde Karakachoff¹⁴, Alban-Elouen Baruteau^{15

16

17

18

19}; DISCO study group

Collaborators

DISCO study group:
Lynne E Nield, Mélanie Grasswill, Bénédicte Romefort, Solène Prigent, Emre Belli, Sonya V Babu-Narayan, Robert W Elder, Magalie Ladouceur, Paul Khairy, Ewa Kowalik, David M Kalfa, Miriam Conway, Oscar Werner, Jean-Marc Sellal, Edward Buratto, David J Barron, Emile A Bacha, Michael A Gatzoulis, Christopher J McLeod, Matilde Karakachoff, Alban-Elouen Baruteau, Sylvia Abadir, Angèle Boet, Anne Charbonneau, Nicolas Combes, Guillaume Duthoit, Christopher C Erickson, Emmanuelle Fournier, Céline Grunenwald, Nadir Benbrik, Juha-Matti Happonen, Bérengère Hiel, Anita Hiippala, Ali Houeijeh, Clément Karsenty, Matthias Lachaud, Mathieu Le Bloa, Laurianne Le Gloan, Leonardo Liberman, Caroline Martin-Bonnet, Philippe Maury, Shafi Mussa, Caroline Ovaert, Robert H Pass, Shubhayan Sanatani, Joel Temple, Jean-Benoit Thambo, Guy Vaksmann, Alain Fraisse, George F Van Hare

Affiliations

¹ Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
² Department of Pediatric Cardiology and Pediatric Cardiac Surgery, Nantes Université, CHU Nantes, FHU PreciCare, Nantes, F-44000, France.
³ Department of Pediatric and Adult Congenital Heart Disease, M3C Marie Lannelongue Hospital, Groupe Hospitalier Saint Joseph, Paris, France.
⁴ National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Hospitals, London, UK.
⁵ Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
⁶ Division of Cardiology, Geneva University Hospital, Geneva, Switzerland.
⁷ Electrophysiology Service and Adult Congenital Heart Center, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
⁸ Department of Congenital Heart Diseases, National Institute of Cardiology, Warsaw, Poland.
⁹ Department of Pediatric and Congenital Cardiac Surgery, Morgan Stanley Children's Hospital - New York Presbyterian, Columbia University Medical Center, New York, NY, USA.
¹⁰ Department of Cardiology, CHRU-Nancy, Université de Lorraine, Nancy, France.
¹¹ Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
¹² Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's & St Thomas' Hospital, London, UK.
¹³ Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
¹⁴ Clinique des Données, CHU Nantes, INSERM, CIC 1413, Nantes, 44093, CIC, France.
¹⁵ Department of Pediatric Cardiology and Pediatric Cardiac Surgery, Nantes Université, CHU Nantes, FHU PreciCare, Nantes, F-44000, France. albanelouen.baruteau@chu-nantes.fr.
¹⁶ Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France. albanelouen.baruteau@chu-nantes.fr.
¹⁷ Nantes Université, CHU Nantes, INSERM, CIC FEA 1413, Nantes, F-44000, France. albanelouen.baruteau@chu-nantes.fr.
¹⁸ Nantes Université, INRAE, UMR 1280, PhAN, Nantes, F-44000, France. albanelouen.baruteau@chu-nantes.fr.
¹⁹ Service médico-chirurgical de cardiologie pédiatrique et congénitale, Centre Hospitalier Universitaire de Nantes, 7 Quai Moncousu, Nantes cedex 01, 44093, France. albanelouen.baruteau@chu-nantes.fr.

PMID: 41779175
DOI: 10.1007/s00246-026-04198-z

No abstract available

Keywords: Congenital heart disease; Congenitally corrected transposition of the great arteries; Heart block; Prenatal diagnosis; Ventricular discordance.