Network toxicology integrated with machine learning and SHAP analysis identifies overlapping immune signatures between Di(2-ethylhexyl) phthalate (DEHP) and Sjögren's syndrome

BMC Pharmacol Toxicol. 2026 Mar 7. doi: 10.1186/s40360-026-01119-x. Online ahead of print.

Cheng Lili¹, Tang Zhongfu¹, Li Ming^{1

2}, Chuanbing Huang^{3

4}

¹ The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
² Institute of Xin'an Medicine and Modernization of Traditional Chinese Medicine, Hefei, Anhui, 230012, China.
³ The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China. chuanbingh@ahtcm.edu.cn.
⁴ Institute of Xin'an Medicine and Modernization of Traditional Chinese Medicine, Hefei, Anhui, 230012, China. chuanbingh@ahtcm.edu.cn.

No abstract available

Keywords: Di(2-ethylhexyl) phthalate; Machine learning; Network toxicology; SHAP analysis; Sjögren's syndrome.

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