Artificial intelligence (AI), an epic frontier in biomedical research, can potentially lead to a paradigm shift in many fields. AI is rapidly reshaping innumerable areas, including that of dermatology, both as a disruptive and assistive technological force. If used properly, AI will be grounded as an effectual tool to be leveraged by physicians in their patient care, enabling optimal diagnostic and treatment outcomes. Skin cancer is among the most prevalent cancers globally, with increasing incidence. AI-based technologies have emerged in recent times to precipitate successful diagnosis of cutaneous malignancies. Here, we review recent advances of AI in dermatology and dermatopathology, its applications in diagnosis, its impact on clinical investigations, usability limitations, and future potential.