17-Year-Old Male Patient With Pulmonary TB Presenting With Tingling and Numbness in the Left Upper Limb

Chest. 2026 Mar;169(3):e103-e107. doi: 10.1016/j.chest.2025.09.125.

Abstract

A 17-year-old male patient, suffering from pulmonary TB and undergoing treatment for the past 4 months, was referred to our institute for further evaluation of potential isoniazid-induced toxicity. The patient reported experiencing left arm pain for the past 2 months, which began gradually and worsened progressively. Initially, the pain was characterized by tingling and numbness, but it developed into severe burning sensations. The patient sought treatment at a local hospital, where the initial impression was that of isoniazid-induced neuropathy. He was managed with pain relief medications, multivitamins, and pyridoxine. Despite this treatment, the patient's pain did not subside and continued to worsen. His ability to grasp objects with his left hand was affected, significantly interfering with his daily activities.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antitubercular Agents* / adverse effects
  • Antitubercular Agents* / therapeutic use
  • Humans
  • Hypesthesia* / chemically induced
  • Isoniazid* / adverse effects
  • Isoniazid* / therapeutic use
  • Male
  • Tuberculosis, Pulmonary* / drug therapy
  • Upper Extremity

Substances

  • Antitubercular Agents
  • Isoniazid