Identification of the Novel HLA-DPB1*1904:01 Allele by Next- and Third-Generation Sequencing

HLA. 2026 Mar;107(3):e70671. doi: 10.1111/tan.70671.

Abstract

HLA-DPB1*1904:01 differs from HLA-DPB1*04:01:01:01 by a single nucleotide substitution in codon 103 within exon 3.

Keywords: HLA‐DPB1*1904:01; HLA; Oxford nanopore technology; novel allele; sequencing‐by‐synthesis.

MeSH terms

  • Alleles*
  • Base Sequence
  • Codon / chemistry
  • Exons*
  • HLA-DP beta-Chains* / genetics
  • High-Throughput Nucleotide Sequencing*
  • Histocompatibility Testing
  • Humans
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA

Substances

  • HLA-DP beta-Chains
  • HLA-DPB1 antigen
  • Codon