The impact of mildly elevated HbA1c level, and low levels of high-density lipoprotein cholesterol and hemoglobin on microvascular angina

Satoru Suzuki; Kenshi Yamanaga; Masanobu Ishii; Erika Matsumoto; Naoto Kuyama; Kyoko Hirakawa; Noriaki Tabata; Tomonori Akasaka; Koichiro Fujisue; Shinsuke Hanatani; Yuichiro Arima; Hiroki Usuku; Eiichiro Yamamoto; Kentaro Oniki; Hirofumi Soejima; Junji Saruwatari; Hiroaki Kawano; Hideaki Jinnouchi; Koichi Kaikita; Hirofumi Yasue; Hisao Ogawa; Kenichi Tsujita

doi:10.1007/s00380-026-02660-9

The impact of mildly elevated HbA1c level, and low levels of high-density lipoprotein cholesterol and hemoglobin on microvascular angina

Heart Vessels. 2026 Mar 15. doi: 10.1007/s00380-026-02660-9. Online ahead of print.

Authors

Satoru Suzuki^#^{1

2}, Kenshi Yamanaga^#¹, Masanobu Ishii^#¹, Erika Matsumoto³, Naoto Kuyama¹, Kyoko Hirakawa¹, Noriaki Tabata¹, Tomonori Akasaka¹, Koichiro Fujisue¹, Shinsuke Hanatani¹, Yuichiro Arima¹, Hiroki Usuku¹, Eiichiro Yamamoto¹, Kentaro Oniki³, Hirofumi Soejima¹, Junji Saruwatari³, Hiroaki Kawano¹, Hideaki Jinnouchi⁴, Koichi Kaikita^{1

5}, Hirofumi Yasue⁶, Hisao Ogawa⁷, Kenichi Tsujita⁸

Affiliations

¹ Department of Cardiovascular Medicine, Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.
² Department of Cardiovascular Medicine, National Hospital Organization Kumamotominami National Hospital, 2338 Toyofuku, Matsubase-machi, Uki City, Kumamoto Prefecture, 869-0593, Japan.
³ Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto City, 862-0973, Japan.
⁴ Diabetes Center, Jinnouchi Hospital, 6-2-3 Kuhonji, Chuo-ku, Kumamoto City, 862-0976, Japan.
⁵ Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki City, 889-1692, Japan.
⁶ Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6-8-1 Yamamuro, Kita-ku, Kumamoto City, 860-8518, Japan.
⁷ Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto City, 860- 8555, Japan.
⁸ Department of Cardiovascular Medicine, Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan. tsujita@kumamoto-u.ac.jp.

^# Contributed equally.

PMID: 41838065
DOI: 10.1007/s00380-026-02660-9

No abstract available

Keywords: Coronary microvascular dysfunction; Glycated hemoglobin; Hemoglobin; High-density lipoprotein cholesterol; Microvascular angina; Microvascular spasm.