PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent

Psychopharmacology (Berl). 1978 Apr 11;56(3):249-53. doi: 10.1007/BF00432846.


The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Benzoates / adverse effects
  • Benzoates / pharmacology*
  • Ethylamines / adverse effects
  • Ethylamines / pharmacology
  • Humans
  • Learning
  • Memory / drug effects*
  • Motor Skills / drug effects
  • Psychotropic Drugs / adverse effects
  • Psychotropic Drugs / pharmacology*
  • Reaction Time / drug effects
  • Retention, Psychology / drug effects*
  • Stimulation, Chemical
  • Time Factors


  • Benzoates
  • Ethylamines
  • Psychotropic Drugs
  • PRL-8-53