Can macrophages predict response to neoadjuvant therapy in lung cancer? A lesson from breast cancer

Cancer Lett. 2026 Mar 18:218438. doi: 10.1016/j.canlet.2026.218438. Online ahead of print.

¹ Department of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, Enna, 94100, Italy. Electronic address: federicopio.fabrizio@unikore.it.
² Department of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, Enna, 94100, Italy; Recovery and Functional Rehabilitation Unit, Umberto I Hospital, Enna, 94100, Italy. Electronic address: francesco.pegreffi@unikore.it.
³ Department of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, Enna, 94100, Italy; Casa di Cura Musumeci GECAS, Gravina di Catania, Catania, Italy. Electronic address: rosario.leonardi@unikore.it.
⁴ IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy. Electronic address: massimiliano.mazza@irst.emr.it.
⁵ Department of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, Enna, 94100, Italy. Electronic address: sara.bravaccini@unikore.it.

No abstract available

Keywords: Immunotherapy resistance; Lung cancer; Macrophages; Neoadjuvant therapy; Spatial transcriptomics; Tumor microenvironment.

Publication types