One-month dual antiplatelet therapy after biodegradable-polymer everolimus-eluting stent implantation in diabetic patients at high bleeding risk

Leon Gramss; Carlo Andrea Pivato; Andrea Pacchioni; Raffaele Piccolo; Carmine Musto; Gennaro Sardella; Ciro Indolfi; Bernhard Reimers; Gianluigi Condorelli; Luca Testa; Carlo Briguori; Giulio Stefanini

doi:10.1093/ehjopen/oeag034

One-month dual antiplatelet therapy after biodegradable-polymer everolimus-eluting stent implantation in diabetic patients at high bleeding risk

Eur Heart J Open. 2026 Feb 21;6(2):oeag034. doi: 10.1093/ehjopen/oeag034. eCollection 2026 Mar.

Authors

Leon Gramss^{1

2}, Carlo Andrea Pivato^{1

2}, Andrea Pacchioni³, Raffaele Piccolo⁴, Carmine Musto⁵, Gennaro Sardella⁶, Ciro Indolfi⁷, Bernhard Reimers², Gianluigi Condorelli^{1

2}, Luca Testa⁸, Carlo Briguori⁹, Giulio Stefanini^{1

2}

Affiliations

¹ Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy.
² Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni, 56, 20089 Rozzano, Milan, Italy.
³ Division of Cardiology, Civil Hospital, Via Luigi Mariutto, 76, 30035 Mirano, Venezia, Italy.
⁴ Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples Federico II, Corso Umberto I 40, 80138 Naples, Italy.
⁵ Cardiology, Ospedale S. Giovanni Evangelista, Via Parrozzani 3, 00019 Tivoli, Rome, Italy.
⁶ Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.
⁷ Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Viale Europa, 88100 Catanzaro, Italy.
⁸ Cardiology Unit, IRCCS Policlinico San Donato, Piazza Edmondo Malan 2, 20097 San Donato Milanese, Milan, Italy.
⁹ Unit of Interventional Cardiology, Mediterranea Cardiocentro, Via Orazio 2, 80122 Naples, Italy.

Abstract

Graphical AbstractCentral Illustration. Primary endpoint was a composite of cardiac death, MI, or definite/probable stent thrombosis. BP-EES: biodegradable-polymer everolimus-eluting stent; CI: confidence interval; CV: cardiovascular; DAPT: dual antiplatelet therapy; HBR: high bleeding risk; HR: hazard ratio; MI: myocardial infarction; PCI: percutaneous coronary intervention; TLF: target lesion failure.For image description, please refer to the figure legend and surrounding text.