A high-content phenotypic screen identifies luteolin as a repurposed drug to reduce pyruvate dehydrogenase phosphorylation and enhance energy production in CMTX6 cell models

J Mol Cell Biol. 2026 Mar 23:mjag012. doi: 10.1093/jmcb/mjag012. Online ahead of print.

Gonzalo Perez-Siles^{1

2}, Masahiro Nishide², Melina Ellis¹, Richard M Wynn³, Gauri Shishodia^{1

3}, Steve Vucic⁴, Marina L Kennerson^{1

2

5}

¹ ANZAC Research Institute, Sydney Local Health District, Concord, NSW 2139, Australia.
² School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2050, Australia.
³ Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, USA.
⁴ Brain and Nerve Research Centre, Concord Repatriation General Hospital, Concord, NSW 2139, Australia.
⁵ Molecular Medicine Laboratory, Concord Repatriation General Hospital, Sydney, NSW 2139, Australia.

No abstract available