Sodium/glucose cotransporters 2 inhibitors but not other antidiabetic drugs improve frailty in older adults with diabetes and heart failure with preserved ejection fraction

Pasquale Mone; Marco Ferrone; Francesco Spione; Dimitris Christodoulakis; Francesco Melillo; Antonio Rainone; Domenico Ponticelli; Tullio Tesorio; Marco Di Mauro; Anna Marro; Gaetano Macina; Maria Morgante; Germano Guerra; Gaetano Santulli

doi:10.1093/cvr/cvag065

Sodium/glucose cotransporters 2 inhibitors but not other antidiabetic drugs improve frailty in older adults with diabetes and heart failure with preserved ejection fraction

Cardiovasc Res. 2026 May 22;122(7):815-818. doi: 10.1093/cvr/cvag065.

Authors

Pasquale Mone^{1

2

3}, Marco Ferrone², Francesco Spione², Dimitris Christodoulakis², Francesco Melillo², Antonio Rainone², Domenico Ponticelli², Tullio Tesorio², Marco Di Mauro³, Anna Marro³, Gaetano Macina³, Maria Morgante^{3

4}, Germano Guerra^{1

5}, Gaetano Santulli^{5

6}

Affiliations

¹ Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via Francesco De Sanctis, 1-86100, Campobasso, Italy.
² Casa di Cura "Montevergine", Via Mario Malzoni, 5-83013, Mercogliano (Avellino), Italy.
³ Local Health Authority (ASL) Avellino, Via DegliImbimbo 10/12-83100, Avellino, Italy.
⁴ Hospital of national relevance and high specialization (AORN) "San Pio", Via Pacevecchia, 57-82100 Benevento, Italy.
⁵ International Translational Research and Medical Education (ITME) Consortium, Joint Academic Research Unit, "Federico II" University, Via Sergio Pansini 5- 80131, Naples, Italy.
⁶ Department of Molecular, Cellular, and Biomedical Sciences; City University of New York (CUNY)-School of Medicine, 160 Convent Avenue-10031, Manhattan (New York), NY, USA.

No abstract available

Keywords: Aging; Cognitive impairment; Endothelial dysfunction; Frailty; Geriatric cardiometabolic health; HFpEF; Inflammation; Physical function; SGLT2 inhibitors; Type 2 diabetes mellitus.

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