On the relationship between glycerophosphoglycolipids and lipoteichoic acids of gram-positive bacteria. III. Di(glycerophospho)-acylkojibiosyldiacylglycerol and related compounds from Streptococcus lactis NCDO 712

Biochim Biophys Acta. 1978 May 25;529(2):250-62. doi: 10.1016/0005-2760(78)90068-1.


1. Streptococcus lactis NCDO 712 contains at lease three unusually polar glycerophosphoglycolipids. One of them was composed of D-glucose, glycerol, fatty acid ester, and phosphorus in the molar ratio of approx. 2 : 3 : 3 : 2. The structure was established as 1,2-di-O-acyl-3-O-[6-(sn-glycero-1-phospho-3-sn-glycero-1-phospho)-alpha-D-glucopyranosyl-(1 leads to 2)-(6-O-acyl-alpha-D-glucopyranosyl)]-glycerol. 2. The second glycerophosphoglycolipid was shown to have the same core structure but is lacking the carbohydrate-linked fatty acid. The third glycero-phosphoglycolipid is a glycosylated derivative of the first one bearing an alpha-galactosyl residue at position 2 of the inner glycolipid-linked glycerophosphate moiety. 3. These novel phosphoglycolipids are considered to be the so far missing link between simple glycerophosphoglycolipids and lipoteichoic acids of Gram-positive bacteria.

MeSH terms

  • Alkalies
  • Chemical Phenomena
  • Chemistry
  • Diglycerides / metabolism
  • Glycolipids / metabolism*
  • Hydrolysis
  • Lactococcus lactis / metabolism*
  • Mass Spectrometry
  • Phosphatidic Acids / metabolism*
  • Phospholipids / metabolism*
  • Teichoic Acids / metabolism*


  • Alkalies
  • Diglycerides
  • Glycolipids
  • Phosphatidic Acids
  • Phospholipids
  • Teichoic Acids