Acid-sensing ion channels and their role in controlling pain in the post-operative stage

Abstract

Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed throughout the nervous system and play a central role in sensory processing, particularly in nociception. Due to their involvement in key physiological processes, ASICs have emerged as promising targets for the modulation of pain perception. Postoperative pain management is primarily dependent on pharmacological agents, such as opioids and nonsteroidal anti-inflammatory drugs (NSAIDs), to alleviate discomfort and facilitate recovery. However, the long-term use of these analgesics is associated with significant risks, including opioid dependence, tolerance, and other adverse effects. As such, the development of non-pharmacological alternatives for pain management is critically needed. Modulating ASIC activity offers a compelling approach to attenuate pain perception, providing an opportunity to reduce reliance on traditional pharmacological agents and their associated side effects. This highlights the importance of further research into ASICs as therapeutic targets for pain management, which could revolutionize postoperative care by offering safer and more effective pain relief strategies.

Keywords: Acid-sensing ion channels; pain; pain modulation; post-operative pain management; surgery.