Primary invasive squamous carcinoma of the vagina

Obstet Gynecol. 1979 Feb;53(2):218-25.


Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%. Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / radiotherapy*
  • Colitis / etiology
  • Colon, Sigmoid
  • Female
  • Humans
  • Middle Aged
  • Neoplasms, Radiation-Induced / etiology
  • Proctitis / etiology
  • Radiotherapy / adverse effects
  • Rectovaginal Fistula / etiology
  • Vaginal Diseases / etiology
  • Vaginal Neoplasms / etiology
  • Vaginal Neoplasms / mortality
  • Vaginal Neoplasms / pathology
  • Vaginal Neoplasms / radiotherapy*
  • Vesicovaginal Fistula / etiology