Vascularized organoids-on-chip aim at assessing systemic drug delivery, but also drug screening, toxicity testing, pharmacokinetics and dynamics, and disease modeling. Here, we provide a detailed experiment protocol to vascularize organoids-on-chip, in regards to pancreatic islet spheroids and hydrogel preparation towards the modelisation of autoimmune diseases, inflammation, immunotherapies.
Keywords: Organoids-on-chip; Pancreatic islet spheroids; Vascularization.
Copyright © 2026. Published by Elsevier Inc.