Reshaping human neurons

Jessica L Maltman; Javier González-Maeso

doi:10.7554/eLife.110981

Reshaping human neurons

Elife. 2026 Mar 31:15:e110981. doi: 10.7554/eLife.110981.

Authors

Jessica L Maltman^{1

2}, Javier González-Maeso²

Affiliations

¹ Biomedical Sciences Graduate Program, Virginia Commonwealth University School of Medicine, Richmond, United States.
² Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, United States.

Abstract

Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.

Keywords: 5-HT2A receptor; BDNF; human; human induced pluripotent stem cell derived cortical neurons; neuroplasticity; neuroscience; psilocin; psychedelics.

Publication types

Editorial

MeSH terms

Hallucinogens* / pharmacology
Humans
Neurons* / cytology
Neurons* / drug effects
Neurons* / physiology
Psilocybin* / analogs & derivatives
Psilocybin* / pharmacology

Substances

Psilocybin
Hallucinogens