Studies on secondary metabolites and anti-inflammatory activity of fungus Penicillium citreosulfuratum YFC-1 from Sphagneticola trilobata

Zhao-Xia Chen; Wen-Xing Li; Ru-Tong Chen; Yang Hui; Zhen-Fan Sun; Wen-Hao Chen

doi:10.1080/14786419.2026.2649401

Studies on secondary metabolites and anti-inflammatory activity of fungus Penicillium citreosulfuratum YFC-1 from Sphagneticola trilobata

Nat Prod Res. 2026 Mar 31:1-9. doi: 10.1080/14786419.2026.2649401. Online ahead of print.

Authors

Zhao-Xia Chen^{1

2}, Wen-Xing Li^{1

2}, Ru-Tong Chen^{1

2}, Yang Hui^{1

2}, Zhen-Fan Sun³, Wen-Hao Chen^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People's Republic of China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People's Republic of China.
³ Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou, People's Republic of China.

PMID: 41915847
DOI: 10.1080/14786419.2026.2649401

Abstract

A novel 4-pyridone alkaloid derivative, microsphaerone H (1), and a new polyketide, annularin O (2), were isolated alongside 17 known compounds (3-19) from an endophytic fungus Penicillium citreosulfuratum YFC-1 of Sphagneticola trilobata. Compounds 4 and 5 were newly identified here as natural products. Their structural elucidation, inclusive of absolute configurations, was achieved via integrated spectroscopic and quantum chemical ECD methodologies. All isolates (1-19) were evaluated for their anti-inflammatory activities. Compounds 4-6, 8, and 13 suppressed LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages, displaying IC₅₀ values of 29.72, 17.99, 49.88, 31.38, and 28.23 µM, respectively.

Keywords: Sphagneticola trilobata; endophytic fungus; penicillium citreosulfuratum.