In morphea, cytotoxic resident memory T cells induce chronic, immunogenic endothelial cell injury via necroptosis

JCI Insight. 2026 Apr 2:e201949. doi: 10.1172/jci.insight.201949. Online ahead of print.

Authors

William J Crisler¹, Noor Sohail², Samuel J Steuart¹, Maria Vazquez-Machado¹, Arjun Mahajan¹, Maureen Whittelsey¹, Alex Pickering¹, Michael J Martinez¹, Theresa Hutchins³, Jessica E Teague¹, Qian Zhan¹, Shannan Ho Sui², Ruth Ann Vleugels¹, Kathryn S Torok³, Heidi Jacobe⁴, Rachael A Clark¹, Avery LaChance¹

Affiliations

¹ Brigham and Women's Hospital and Harvard Medical School, Boston, United States of America.
² Harvard Chan School of Public Health, Boston, United States of America.
³ University of Pittsburgh Medical Center, Pittsburgh, United States of America.
⁴ University of Texas Southwestern Medical Center, Dallas, United States of America.

PMID: 41926212
DOI: 10.1172/jci.insight.201949

No abstract available

Keywords: Cell stress; Cellular immune response; Dermatology; Fibrosis; Immunology.