Accuracy of rapid plasma reagin titers for identifying untreated syphilis in a routine screening population

Sex Transm Dis. 2026 Apr 3. doi: 10.1097/OLQ.0000000000002310. Online ahead of print.

Abstract

This study assessed the performance of syphilis serology alone versus the gold standard of a reactive RPR plus clinical history for identifying active syphilis infections in a universal emergency department screening setting, an approach that could be helpful for researchers analyzing large datasets or clinicians working in limited resource settings.

Keywords: Emergency Department; Rapid Plasma Reagin; STI; Syphilis; Universal Screening.