Redefining the Landscape of Genitourinary Cancer Precursors: The International Society of Urological Pathology Consensus Recommendations

Liang Cheng; Kenneth A Iczkowski; Geert J L H van Leenders; Michelle R Downes; Maria R Raspollini; Sean R Williamson; Holger Moch; Felix Bremmer; Satish K Tickoo; Santosh Menon; Antonio L Cubilla; Glen Kristiansen; Members of ISUP GU Cancer Precursor Consensus Panel

doi:10.1016/j.eururo.2026.03.006

Redefining the Landscape of Genitourinary Cancer Precursors: The International Society of Urological Pathology Consensus Recommendations

Eur Urol. 2026 Jun;89(6):483-486. doi: 10.1016/j.eururo.2026.03.006. Epub 2026 Apr 3.

Collaborators

Members of ISUP GU Cancer Precursor Consensus Panel:
Andres Acosta, Adebowale Adeniran, Nabil Adra, Neeraj Agarwal, Mahmut Akgul, Hikmat Al-Ahmadie, Ferran Algaba, Yves Allory, Khaleel Al-Obaidy, Mahul Amin, Georgios Andreou, Marc Barry, Dilek Baydar, David Berman, Stephania Bezerra, Felix Bremmer, James Brugarolas, Matteo Brunelli, Lukas Bubendorf, Katie Buzacott, Birgitte Carlsen, Alcides Chaux, Fei Chen, Liang Cheng, Arul Chinnaiyan, Roselyne Choiniere, Alessia Cimadamore, Maurizio Colecchia, Katrina Collins, Eva Comperat, Roberto Contieri, Michael Cookson, Antonio Cubilla, Francesca D'Souza, Alis Dema, Angelo DeMarzo, Gedske Daugaard, Regina de Paula Xavier Gomes, Klaus-Peter Dieckmann, Dejan Dobi, Michelle Downes, Andrew Erickson, Bishoy Faltas, Alexander Fichhtner, Samson Fine, Achim Fleischmann, Jacqueline Fontugne, Rongbin Ge, Gianluca Giannarini, Giovanna Giannico, Timothy Gilligan, Jennifer Gordetsky, Nancy Greenland, Raluca Grigorescu, Rainer Grobholz, Charles Guo, Sounak Gupta, Lavinia Hallam, Ari Hakimi, Donna Hansel, Arndt Hartmann, Loren Herrera Hernandez, Jiaoti Huang, Kenneth Iczkowski, Rafael Jimenez, Merce Jorda, Ashish Kamat, Payal Kapur, Seema Kaushal, James Kench, Margaret Knowles, Glen Kristiansen, Li Lei, Subodh Lele, João Lobo, Massimo Loda, Leendert Looijenga, Antonio Lopez-Beltran, Tamara Lotan, Anand Loya, Fiona Maclean, Alopa Malaviya, Guido Martignoni, Rohit Mehra, Santosh Menon, Laura Mertens, Holger Moch, Sambit Mohanty, Rodolfo Montironi, Helmut Mühleisen, Andrea Necchi, George Netto, Ngoc-Nhu Jennifer Nguyen, Maya Nourieh, Mikko Nyman, Pedro Oliveira, Declan O'Rourke, Adeboye Osunkoya, Gladell Paner, Ewa Rajpert-De Meyts, Maria Rosaria Raspollini, Timothy Ratliff, Sigrid Regauer, Henning Reis, Ohashi Riuko, Antonio Rodriguez-Calero, Jeffrey Ross, Diego Sanchez, Ankur Sangoi, Fanni Sánta, Steven Shen, Brian Shuch, Steven Smith, Philippe Spiess, John Srigley, Yue Sun, Sueli Suzigan, Nicole Swarbrick, Pheroze Tamboli, Puay Hoon Tan, Zahrah Tawil, Satish Tickoo, Maria Tretiakova, Isabel Trias, Lawrence True, Toyonori Tsuzuki, Monika Ulamec, Theodorus Van der Kwast, Geert Jlh van Leenders, Bas van Rhijn, Funda Vakar Lopez, Murali Varma, Elsa Velazquez, Mariavittoria Vescovo, Gang Wang, Anne Warren, Joshua Warrick, Sean Williamson, Sara Wobker, Chin-Lee Wu, Huihui Ye, Xiaolin Zi, Hong Zhang

Affiliations

¹ Department of Pathology and Laboratory Medicine, Department of Surgery (Urology), Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, RI, USA. Electronic address: liang_cheng@yahoo.com.
² Department of Pathology and Laboratory Medicine, University of California-Davis Health, Sacramento, CA, USA.
³ Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
⁴ Division of Anatomic Pathology, Department of Laboratory Medicine and Molecular Diagnostics, Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
⁵ Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy.
⁶ Department of Pathology, Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA.
⁷ Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
⁸ Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
⁹ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁰ Department of Pathology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹¹ Instituto de Patología e Investigación, Asunción, Paraguay and Universidad Nacional de Asunción, San Lorenzo, Paraguay.
¹² Institute of Pathology, University Hospital Bonn, Bonn, Germany.

PMID: 41934039
DOI: 10.1016/j.eururo.2026.03.006

Abstract

The International Society of Urological Pathology Florence Multidisciplinary Consensus Conference establishes a contemporary framework for the definition and standardized reporting of genitourinary cancer precursor lesions. These consensus recommendations provide evidence-based guidance for diagnostic practice, inform clinical management, and define priorities for future research in genitourinary premalignancy.

Publication types

Consensus Statement

MeSH terms

Humans
Precancerous Conditions* / diagnosis
Precancerous Conditions* / pathology
Precancerous Conditions* / therapy
Societies, Medical
Urogenital Neoplasms* / diagnosis
Urogenital Neoplasms* / pathology
Urogenital Neoplasms* / therapy
Urology* / standards