A Shot in the Dark: Unprecedented Complete Radiologic Response of Metastatic Prostate Cancer to Single-Dose Androgen Deprivation Therapy (ADT)

Abstract

Androgen deprivation therapy (ADT) is a well-established treatment strategy for metastatic prostate cancer, aimed at reducing tumor burden and alleviating symptoms. Although ADT is a cornerstone in managing prostate cancer, complete radiological regression of metastatic disease, with a single dose of ADT, has not been previously reported. We present an exceptional case of a patient with metastatic prostate cancer who achieved a complete radiological response to ADT, highlighting an extraordinary therapeutic outcome.

Keywords: androgen deprivation therapy; metastatic; prostate cancer; psa; psma-pet-ct.