Transcriptional regulator Rv2250c affects isoniazid resistance by down-regulating the expression of efflux pump Rv3728 in Mycobacterium tuberculosis

Arch Microbiol. 2026 Apr 7;208(6):304. doi: 10.1007/s00203-026-04866-x.

¹ State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
² Bioengineering Department, School of Life Science and Technology, Shandong Second Medical University, Weifang, 261000, China.
³ State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. liusiguo@caas.cn.

^# Contributed equally.

No abstract available

Keywords: Mycobacterium tuberculosis; Efflux pump Rv3728; Isoniazid; Transcriptional regulatory protein Rv2250c.

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