Malignant Melanoma With Rhabdomyosarcomatous Differentiation: Report of 2 New Cases

Maged Daruish; Hazem Ibrahim

doi:10.1097/DAD.0000000000003292

Malignant Melanoma With Rhabdomyosarcomatous Differentiation: Report of 2 New Cases

Am J Dermatopathol. 2026 Apr 8. doi: 10.1097/DAD.0000000000003292. Online ahead of print.

Authors

Maged Daruish^{1

2}, Hazem Ibrahim³

Affiliations

¹ Cellular Pathology Department, Dorset County Hospital Foundation NHS Trust, Dorchester, United Kingdom.
² Poundbury Cancer Institute, Dorchester, United Kingdom; and.
³ Departments of Histopathology and Dermatology, Royal Free London NHS Foundation Trust, London, United Kingdom.

PMID: 41950050
DOI: 10.1097/DAD.0000000000003292

Abstract

Divergent differentiation in primary cutaneous malignant melanoma is a rare phenomenon that can pose a significant diagnostic challenge. We present two new cases of primary cutaneous malignant melanoma with rhabdomyosarcomatous differentiation, highlighting its aggressive nature. Thorough histological sampling and inclusion of skeletal muscle immunostains are essential for accurate diagnosis, particularly when rhabdoid morphology is identified.

Keywords: divergent differentiation; malignant melanoma; rhabdomyosarcoma.