Systems biology in the era of AI: "winter" or "evolution"?

Front Syst Biol. 2026 Mar 24:6:1818525. doi: 10.3389/fsysb.2026.1818525. eCollection 2026.

Mohamed Helmy^{1

2

3

4

5

6}, Kumar Selvarajoo^{6

7

8

9}

¹ Vaccine and Infectious Diseases Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.
² Vaccinology and Immunotherapeutics Program, School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada.
³ Department of Computer Science, University of Saskatchewan, Saskatoon, SK, Canada.
⁴ Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
⁵ Department of Computer Science, Idaho State University, Pocatello, ID, United States.
⁶ Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
⁷ Synthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
⁸ Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore (NUS), Singapore, Singapore.
⁹ School of Biological Sciences, Nanyang Technological University (NTU), Singapore, Singapore.

No abstract available

Keywords: artificial intelligence - AI; bioinformatics; data science; modelling; systems biology.