Three donor-matched iPSC lines derived from human postmortem dura mater for modeling neurodegenerative diseases

Yu-Mi Shim; Sooyeon Yoo; Hyung-Jin Kwon; Kwanghoon Lee; Sung-Hye Park; Jae-Kyung Won

doi:10.1016/j.scr.2026.103984

Three donor-matched iPSC lines derived from human postmortem dura mater for modeling neurodegenerative diseases

Stem Cell Res. 2026 Apr 2:94:103984. doi: 10.1016/j.scr.2026.103984. Online ahead of print.

Authors

Yu-Mi Shim¹, Sooyeon Yoo¹, Hyung-Jin Kwon², Kwanghoon Lee¹, Sung-Hye Park³, Jae-Kyung Won⁴

Affiliations

¹ Department of Pathology, Seoul National University Hospital, Seoul, the Republic of Korea; Brain Bank, Seoul National University Hospital, Seoul, the Republic of Korea.
² Brain Bank, Seoul National University Hospital, Seoul, the Republic of Korea.
³ Department of Pathology, Seoul National University Hospital, Seoul, the Republic of Korea; Brain Bank, Seoul National University Hospital, Seoul, the Republic of Korea. Electronic address: shparknp@snu.ac.kr.
⁴ Department of Pathology, Seoul National University Hospital, Seoul, the Republic of Korea; Brain Bank, Seoul National University Hospital, Seoul, the Republic of Korea. Electronic address: jkwon@snuh.org.

PMID: 41955966
DOI: 10.1016/j.scr.2026.103984

Abstract

We generated three donor-matched induced pluripotent stem cell (iPSC) lines from postmortem dura-derived fibroblasts obtained from donors with neuropathologically confirmed Alzheimer's disease (AD), Parkinson's disease (PD), and primary age-related tauopathy (PART) with TDP-43 co-pathology. All lines exhibited characteristic features of the undifferentiated human pluripotent stem cell (hPSC) state and maintained donor-specific genomic identity with stable variant profiles. These well-characterized iPSC lines provide valuable resources for modeling neurodegenerative diseases and for generating isogenic neural derivatives comparable to autopsy brain tissues from the same individuals.