[Glioblastoma with loss of H3K27me3 and EGFR exon 20 insertion: report of a case]

T R Hu; F Li; Y Lan; J Ge; F Liu; A L Li; L H Wang; J Wang; S Wei; D M Chai; X W Bian; T Luo

doi:10.3760/cma.j.cn112151-20250725-00507

[Glioblastoma with loss of H3K27me3 and EGFR exon 20 insertion: report of a case]

Zhonghua Bing Li Xue Za Zhi. 2026 Apr 8;55(4):386-389. doi: 10.3760/cma.j.cn112151-20250725-00507.

[Article in Chinese]

Authors

T R Hu¹, F Li², Y Lan¹, J Ge¹, F Liu¹, A L Li¹, L H Wang¹, J Wang¹, S Wei¹, D M Chai³, X W Bian¹, T Luo¹

Affiliations

¹ Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China.
² Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
³ Department of Pathology, School of Basic Medicine, Bengbu Medical University, Bengbu 233000, China.

PMID: 41956756
DOI: 10.3760/cma.j.cn112151-20250725-00507

Abstract

胶质母细胞瘤（GBM）是一种原发于中枢神经系统的成人型高级别恶性胶质瘤。本文报道1例50岁女性GBM患者，不仅具有GBM的组织学形态及分子特征，同时存在弥漫性中线胶质瘤的特征性的H3K27me3表达缺失及EGFR 20号外显子插入突变（p.P772_C775dup）。进行多种DNA甲基化谱聚类分析，发现该病例可能具有独特的甲基化谱特征。.

Publication types

Case Reports

MeSH terms

Brain Neoplasms* / genetics
Brain Neoplasms* / metabolism
Brain Neoplasms* / pathology
DNA Methylation*
ErbB Receptors* / genetics
ErbB Receptors* / metabolism
Exons
Female
Glioblastoma* / genetics
Glioblastoma* / metabolism
Glioblastoma* / pathology
Glioblastoma* / surgery
Histones* / metabolism
Humans
Middle Aged
Mutagenesis, Insertional*

Substances

ErbB Receptors
Histones
EGFR protein, human