Perioperative Management of Cryopyrin-Associated Periodic Syndrome, Muckle-Wells Subtype: A Case Report

Jason A Levin; Victoria N Huynh; Ashish Sakharpe; Efrain Riveros Perez; Jasmeen Kaur

doi:10.1213/XAA.0000000000002194

Perioperative Management of Cryopyrin-Associated Periodic Syndrome, Muckle-Wells Subtype: A Case Report

A A Pract. 2026 Apr 10;20(4):e02194. doi: 10.1213/XAA.0000000000002194. eCollection 2026 Apr 1.

Authors

Jason A Levin¹, Victoria N Huynh¹, Ashish Sakharpe², Efrain Riveros Perez³, Jasmeen Kaur²

Affiliations

¹ From the Department of Anesthesiology & Perioperative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia.
² Department of Anesthesiology & Perioperative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia.
³ Department of Anesthesiology, Memorial Health University Medical Center, Savannah, Georgia.

PMID: 41961992
DOI: 10.1213/XAA.0000000000002194

Abstract

Cryopyrin-associated periodic syndrome (CAPS) is a rare family of autoinflammatory disorders characterized by constitutive inflammasome activation that can be triggered by exposure to cold temperatures. We discuss the case of a 49-year-old woman with Muckle-Wells syndrome, a subtype of CAPS, presenting for cervical lymph node biopsy to rule out lymphoma. The pathophysiology of CAPS, intraoperative temperature monitoring, and other anesthesia considerations are reviewed in this article.

Publication types

Case Reports

MeSH terms

Cryopyrin-Associated Periodic Syndromes* / diagnosis
Cryopyrin-Associated Periodic Syndromes* / surgery
Female
Humans
Lymph Nodes / pathology
Middle Aged
Perioperative Care* / methods