Abstract
Escherichia coli mutants have been isolated that are permissive for the infection by T4 phage with deletion in the cistron for the phage lysozyme, the e gene. Some, but not all, of these mutants are simultaneously permissive for the infection by T4 phage defective in the t gene, the product of which has also been implicated in the release of progeny phages. Most of these mutants shared the following properties: temperature sensitivity in growth and cell division, increased sensitivity towards a number of unrelated antibiotics and colicins, and increased sensitivity towards anionic detergents (sodium dodecyl sulfate and sodium deoxycholate). The possible biochemical basis for these phenotypes is discussed.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Cell Division
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Colicins / pharmacology
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Coliphages / enzymology*
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Coliphages / growth & development
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DNA Viruses / enzymology*
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DNA Viruses / growth & development
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Drug Resistance, Microbial
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Edetic Acid / pharmacology
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Escherichia coli* / drug effects
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Escherichia coli* / enzymology
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Escherichia coli* / growth & development
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Genes
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Glucose-6-Phosphate Isomerase / metabolism
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Lysogeny*
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Muramidase / biosynthesis*
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Muramidase / pharmacology
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Mutagens
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Mutation*
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Nitrosoguanidines
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Ribonucleases / metabolism
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Surface-Active Agents / pharmacology
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Temperature
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Tritium
Substances
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Anti-Bacterial Agents
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Colicins
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Mutagens
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Nitrosoguanidines
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Surface-Active Agents
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Tritium
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Edetic Acid
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Ribonucleases
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Muramidase
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Glucose-6-Phosphate Isomerase