Single-cell and spatial transcriptomics reveal TNF-α promotes glioblastoma proliferation and migration via CP-mediated KLF10 upregulation

Affiliations

• ¹ Department of Neurosurgery, Second Clinical Medical College of Southern Medical University, Zhujiang Hospital, Guangzhou, China.
• ² The National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neuro-oncological Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
• ³ Department of Physiology, Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China.
• ⁴ Department of Neurosurgery, Second Clinical Medical College of Southern Medical University, Zhujiang Hospital, Guangzhou, China. kyquan@smu.edu.cn.
• ⁵ The National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neuro-oncological Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. kyquan@smu.edu.cn.
• ⁶ Department of Neurosurgery, Second Clinical Medical College of Southern Medical University, Zhujiang Hospital, Guangzhou, China. remmusxl@smu.edu.cn.
• ⁷ The National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neuro-oncological Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. remmusxl@smu.edu.cn.