mRNA vaccination targeting AML1::ETO fusion gene eliminates leukemia cells via activating T cells

Leukemia. 2026 Jun;40(6):1335-1339. doi: 10.1038/s41375-026-02940-3. Epub 2026 Apr 10.

Changli Zhou^#¹, Sicheng Bian^#¹, Jiuxia Pang^#¹, Huiqin Bian¹, Tao Cheng¹, Hiroaki Koyama¹, Bin Liu², Bing Li³, William Tse^{1

4}, Shujun Liu^{5

6}

¹ Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
² Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN, 55912, USA.
³ Department of Pathology, The University of Iowa, 431 Newton Road, Iowa City, IA, 52242, USA.
⁴ Gene and Cell Therapy Institute, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
⁵ Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA. shujun.liu2@case.edu.
⁶ Gene and Cell Therapy Institute, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA. shujun.liu2@case.edu.

Abstract