Bridging the gap between neuroscience and clinical practice: a review of the development of Temperament Based Therapy with Support (TBT-S)

Kristin Stedal; Christina E Wierenga; Stephanie Knatz Peck; Laura Hill

doi:10.1186/s40337-026-01592-z

Bridging the gap between neuroscience and clinical practice: a review of the development of Temperament Based Therapy with Support (TBT-S)

J Eat Disord. 2026 Apr 12. doi: 10.1186/s40337-026-01592-z. Online ahead of print.

Authors

Kristin Stedal¹, Christina E Wierenga², Stephanie Knatz Peck², Laura Hill³

Affiliations

¹ Regional Department of Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. kristin.stedal@ous-hf.no.
² Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
³ Department of Psychiatry and Behavioral Health, The Ohio State University W. Medical Center, Columbus, OH, USA.

PMID: 41968329
DOI: 10.1186/s40337-026-01592-z

Abstract

Temperament Based Therapy with Support (TBT-S) is an emerging, personalized treatment approach for eating disorders (EDs) that integrates patients' temperamental traits and neurobiological research into therapeutic strategies to reduce symptoms. While research on the efficacy of TBT-S is still in its infancy, the development of TBT-S as a treatment for EDs spans over two decades. The approach is unique in that it was formulated from neurobiological research, and utilizes treatment tools which were created collaboratively with individuals with lived experience. Hence, the aim of this review of the development of TBT-S is to share how clinical interventions can evolve from basic science through collaboration with the target population. The review provides a structured synthesis of how TBT-S progressed and explores the most current evidence and avenues for future research.

Keywords: Anorexia nervosa; Eating disorders; Multifamily treatment; Temperament based treatment.

Publication types

Review